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  <front>
    <journal-meta>
      <journal-id journal-id-type="publisher-id">cjbr</journal-id>
      <journal-title-group>
        <journal-title>Cascadia Journal of Biomedical Research</journal-title>
        <abbrev-journal-title abbrev-type="publisher">Cascadia J. Biomed. Res.</abbrev-journal-title>
      </journal-title-group>
      <issn publication-format="electronic">2693-8510</issn>
      <publisher>
        <publisher-name>Cascadia Health Sciences Publishing</publisher-name>
      </publisher>
    </journal-meta>
    <article-meta>
      <article-id pub-id-type="doi">10.58302/sa7wvg60</article-id>
      <title-group>
        <article-title>A randomized trial of Parkinson’s disease across three population-based cohorts</article-title>
      </title-group>
      <contrib-group>
        <contrib contrib-type="author" corresp="yes">
          <contrib-id contrib-id-type="orcid" authenticated="false">https://orcid.org/0015-0001-5584-5927</contrib-id>
          <name>
            <surname>Nguyễn</surname>
            <given-names>Minh</given-names>
          </name>
          <role vocab="credit" vocab-identifier="https://credit.niso.org/" vocab-term="Writing – original draft" vocab-term-identifier="https://credit.niso.org/contributor-roles/writing-original-draft/">Writing – original draft</role>
          <role vocab="credit" vocab-identifier="https://credit.niso.org/" vocab-term="Software" vocab-term-identifier="https://credit.niso.org/contributor-roles/software/">Software</role>
          <xref ref-type="aff" rid="aff1"/>
        </contrib>
        <contrib contrib-type="author">
          <name>
            <surname>Okafor</surname>
            <given-names>Thandiwe</given-names>
          </name>
          <xref ref-type="aff" rid="aff2"/>
        </contrib>
        <contrib contrib-type="author">
          <name>
            <surname>Johansson</surname>
            <given-names>Stefan</given-names>
          </name>
          <role vocab="credit" vocab-identifier="https://credit.niso.org/" vocab-term="Methodology" vocab-term-identifier="https://credit.niso.org/contributor-roles/methodology/">Methodology</role>
          <role vocab="credit" vocab-identifier="https://credit.niso.org/" vocab-term="Project administration" vocab-term-identifier="https://credit.niso.org/contributor-roles/project-administration/">Project administration</role>
          <role vocab="credit" vocab-identifier="https://credit.niso.org/" vocab-term="Visualization" vocab-term-identifier="https://credit.niso.org/contributor-roles/visualization/">Visualization</role>
          <xref ref-type="aff" rid="aff3"/>
        </contrib>
        <aff id="aff1">School of Economics, Hanseatic University of Applied Sciences, Germany</aff>
        <aff id="aff2">Department of Biomedical Sciences, Sapienza Mediterranea, Italy</aff>
        <aff id="aff3">Department of Linguistics, University of Eastfield, United Kingdom</aff>
      </contrib-group>
      <author-notes>
        <fn fn-type="coi-statement">
          <p>The authors declare no competing interests.</p>
        </fn>
      </author-notes>
      <pub-date publication-format="electronic" date-type="pub" iso-8601-date="2026-03-23">
        <day>23</day>
        <month>03</month>
        <year>2026</year>
      </pub-date>
      <volume>18</volume>
      <issue>1</issue>
      <pub-history>
        <event>
          <date date-type="received" iso-8601-date="2025-11-05">
            <day>05</day>
            <month>11</month>
            <year>2025</year>
          </date>
        </event>
        <event>
          <date date-type="accepted" iso-8601-date="2026-02-02">
            <day>02</day>
            <month>02</month>
            <year>2026</year>
          </date>
        </event>
      </pub-history>
      <permissions>
        <copyright-statement>© 2026 Cascadia Health Sciences Publishing</copyright-statement>
        <copyright-year>2026</copyright-year>
        <copyright-holder>Cascadia Health Sciences Publishing</copyright-holder>
        <ali:free_to_read/>
        <license>
          <ali:license_ref>https://creativecommons.org/licenses/by-nc/4.0/</ali:license_ref>
        </license>
      </permissions>
      <abstract>
        <p>Hypertension have attracted growing attention because of their relevance to both theory and practice. In contrast to earlier studies, our approach accounts for heterogeneity and avoids the usual simplifying assumptions. We find a distinct transcriptional program in the responding group. We discuss limitations of the present study and outline how the methods can be extended.</p>
      </abstract>
      <kwd-group kwd-group-type="author">
        <kwd>randomized controlled trial</kwd>
        <kwd>COVID-19 vaccination</kwd>
        <kwd>cohort study</kwd>
        <kwd>inflammation</kwd>
        <kwd>gene expression</kwd>
      </kwd-group>
    </article-meta>
  </front>
  <back>
    <sec sec-type="data-availability">
      <title>Data Availability</title>
      <p>Source code and data are available at a public repository; the link is provided in the Methods section.</p>
    </sec>
    <sec sec-type="ethics-statement">
      <title>Ethics statement</title>
      <p>No ethics approval was required for this study.</p>
    </sec>
  </back>
</article>
